In a multivariable Cox regression survival model based on SPRED1 mutation status, overall stage, age, gender and specimen type (primary or recurrence/metastasis), SPRED1 aberrations co-occurring with NRAS/NF1/KIT mutations were associated with increased risk of melanoma-specific mortality (p = 0.006) (Fig. 6c). Here, NF1 is linked to melanoma.