These are particularly interesting in that the Dact3 gene is essential for normal brain development, and important in embryonic development of the central nervous system70, while COG3, a part of the COG complex, interacts with Biogenesis of Lysosome-Related Organelles Complex 1 (BLOC-1), which contains the schizophrenia susceptibility factor dysbindin. Here, DACT3 is linked to schizophrenia.