Furthermore, we examined the expression of CDK4 and CyclinD1 which were related with G1/G0 phase by western blotting, and it showed that CDK4 and CyclinD1 were decreased in GBC-SD cells transfected with si-PVT1-1, and vice versa in SGC-996 cells transfected with pcDNA-PVT1 (Fig. 2G). The gene discussed is CDK4; the disease is Salla disease.