GSK3B and Alzheimer disease: Furthermore, in these studies, BDNF transport impairment was prevented by inhibiting glycogen synthase kinase 3β (GSK3β), a kinase that is implicated in many aspects of AD pathogenesis (Maqbool et al., 2016) and regulates kinesin-1 interactions with cargo and microtubules (Morfini et al., 2002; Weaver et al., 2013).