We here report that patients with RA have increased proportions of both Th1 and non-classical CXCR3+Th2 cells in SF compared to blood and that the majority of TPh and PD-1highTFh cells in RA SF are of a Th1 or CXCR3+Th2 phenotype. This evidence concerns the gene CXCR3 and rheumatoid arthritis.