SHMT2 was up-regulated in 7 various kidney cancer datasets, compared to normol tissues (P‐value < 0.05 and Fold change > 2) including Renal Wilms Tumor [11], Clear Cell Renal Cell Carcinoma [11–13], Non-Hereditary Clear Cell Renal Cell Carcinoma [14] and Hereditary Clear Cell Renal Cell Carcinoma [14] (Fig. 1a-g). Here, SHMT2 is linked to hereditary clear cell renal cell carcinoma.