By examining the microarray data from cBioPortal online database for renal clear cell carcinoma (TCGA, Provisional), we identified the top 10 genes with positive correlation to SHMT2 expression in renal clear cell carcinoma, including NDUFA4L2, TCEA3, RACK1, HYI, LRRC23, RPLP0, ALDOA, PHB2, UBXN6 and RPS5 (Table 1). The gene discussed is PHB2; the disease is clear cell renal carcinoma.