In agreement with De Vos and colleagues, a recent report showed that NGR/BACE1 ratio levels are (i) elevated in both individuals with subjective cognitive decline (SCD) and MCI compared to HC individuals, (ii) associated with smaller hippocampal and amygdala volumes, and (iii) correlate with worse baseline and longitudinal cognitive performance [28]. The gene discussed is BACE1; the disease is Mental deterioration.