Patients with HFpEF and a low MR-proANP did not have a significantly different risk for an incident CV event compared to patients without HF (univariable analysis; HR 1.30 [0.48–3.56], multivariable model; HR 2.18 [0.78–6.14], p > 0.05) (Fig. 3). This evidence concerns the gene NR3C2 and hydrops fetalis.