Similarly, in a prospective cohort of more than 700 outpatients with T2D in secondary care in Austria, a one standard deviation increase in MR-proANP was associated with a 1.85-fold [1.49–2.30] increase in the risk of the composite outcome of unplanned hospitalization for CV disease or death during a median follow-up of 15 months, in a multivariable model adjusted for NYHA functional class, age, serum creatinine level, low-density lipoprotein level, level of serum triglycerides, hemoglobin A1c, SBP and BMI [22]. This evidence concerns the gene NPPA and type 2 diabetes mellitus.