NPPA and type 2 diabetes mellitus: Based on the prognostic data in this large cohort of outpatients with T2D, an MR-proANP level of 60 pmol/l can support the diabetologist in identifying patients with HFpEF and increased risk of CV events, thus acting as a guide to identify patients for further cardiac diagnostic work up; patients with dyspnea and an MR-proANP of 60 pmol/l or greater should be referred for an echocardiogram.