In the current study elevated MR-proANP levels were associated with a lower risk of incident T2D, elevated copeptin levels were associated with a higher risk of incident prediabetes/T2D, and elevated CT-proET-1 and MR-proADM levels were associated with increases in several traits of insulin resistance during the follow-up period. The gene discussed is NPPA; the disease is type 2 diabetes mellitus.