The present study aimed to evaluate plasma levels of MR-proANP, copeptin, CT-proET-1 and MR-proADM for their putative associations with incident T2D, the combined endpoint of incident prediabetes/T2D and traits of glycaemia and insulin resistance (fasting and 2 h-glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and β-cell function (HOMA-B) and haemoglobin A1c (HbA1c)) at follow-up. The gene discussed is INS; the disease is prediabetes syndrome.