Several novel cardiac stress biomarkers like C-terminal pro-arginine-vasopressin (copeptin), C-terminal pro-endothelin-1 (CT-proET-1) and mid-regional pro-adrenomedullin (MR-proADM) were positively associated with metabolic syndrome and insulin resistance in cross-sectional settings [5, 6]. The gene discussed is AVP; the disease is Insulin resistance.