Furthermore, out of 1495 normoglycaemic participants with MR-proANP measurement, 266 developed prediabetes/T2D, and out of 802 participants with copeptin, CT-proET-1 and MR-proADM measurements, 145 developed prediabetes/T2D during follow-up. This evidence concerns the gene AVP and type 2 diabetes mellitus.