The cfDNA content was strongly correlated with the levels of CEA (P < 0.0001, Pearson r = 0.84), LDH (P < 0.0001, Pearson r = 0.86) and the sum of tumor diameters (P < 0.0001, Pearson r = 0.76) (Table 4 and Fig. 2a). The gene discussed is CEACAM5; the disease is neoplasm.