Some of the top-ranked significant genes, e.g., HLA-DRB3, HLA-DRB5, and HLA-DRB4, have been widely documented to be involved in mild asthma pathogenesis in previous studies [2, 11–16, 52], which is in line with previous finding that there exist shared genetic components between mild and moderate-to-severe asthma [47]. Here, HLA-DRB5 is linked to asthma.