For example, the top-ranked risk genes with significant eSNPs conferring risk to asthma: HLA-DRB3/HLA-DRB5/HLA-DRB4/HLA-DRB1 (Simulated P = 7.93 × 10− 7), RBM43 (Simulated P = 1.59 × 10− 6), HLA-DOB (Sherlock-based P = 1.59 × 10− 6), IKZF3 (Simulated P = 1.59 × 10− 6), IL18R1 (Simulated P = 1.59 × 10− 6), GNGT2 (Simulated P = 1.11 × 10− 5), MAP2K5 (Simulated P = 2.54 × 10− 5), and HLA-DQA1 (Simulated P = 2.85 × 10− 5). The gene discussed is HLA-DRB1; the disease is asthma.