In our current analysis, there were 4 eSNPs of rs5743595 (PeQTL = 4.5 × 10− 7 and PGWAS = 2.61 × 10− 3), rs11130280 (PeQTL = 5.0 × 10− 6 and PGWAS = 1.83 × 10− 2), rs5743592 (PeQTL = 3.0 × 10− 6 and PGWAS = 2.49 × 10− 3), and rs11466640 (PeQTL = 1.64 × 10− 7 and PGWAS = 2.0 × 10− 3) in TLR6 associated with moderate-to-severe asthma risk. The gene discussed is TLR6; the disease is asthma.