Subsequently, through performing joint bioinformatics analyses, including MAGMA gene analysis, pathway enrichment analysis, in silico permutation analysis, PPI network analysis, co-expression analysis, and DEG analysis, we highlighted 11 important genes, such as GNGT2, TLR6, and TTC19, may represent authentic risk genes for moderate-to-severe asthma. The gene discussed is TLR6; the disease is asthma.