ABCA1 and Tangier disease: In addition to Tangier disease [20,21], variations and alterations in the ABCA1 gene enhance the risk of allelic disorders, such as atherosclerosis [22,23], ischemic stroke [23,24], coronary heart disease [25], type II diabetes [26,27,28], myocardial infarction (MI) [6], familial hypercholesterolaemia (FH) [29], cancer [30,31,32], Alzheimer’s disease [33], and macular degeneration [34].