MV-NIS is another modification of the MV-Edm, in this case the recombinant virus expresses the human sodium iodide symporter (NIS) to improve the monitoring of MV infection in vivo in brain tumors with a non-invasive method by using systemic administration of 123I, 124I, 125I, or 99mTc isotopes and measuring the isotope accumulation in virus-replicating cells. Here, SLC5A5 is linked to brain neoplasm.