Tetrandine and DIM phosphorylate protein tyrosine kinase c-src, which then dissociates from Ahr-c-src complex and induces AhR-mediated activation of E3 ubiquitin ligase c-CBL and subsequent ubiquitination and degradation of Syk, inhibiting osteoclastogenesis (through inhibition of NFATc1) and bone destruction in arthritis. Here, AHR is linked to Arthritis.