While most of the studies that have analyzed the relationship between aPLs and obstetric complications of APS, or PE, have focused on the antibodies included as diagnosis criteria for APS (AL, aCL or aβ2GPI) and mainly on the estimation of IgG and IgM isotypes, only a few studies have analyzed the pathogenic importance of the IgA isotype of aPLs [57,58]. The gene discussed is ACLY; the disease is autoimmune polyendocrinopathy.