These radiolabeled compounds allow the visualization of the amino acid radiopharmaceuticals uptake mediated by the L-type amino acid transporter 1 and 2 (LAT1 and LAT2) and related to the augmented protein synthesis in brain tumor cells; nevertheless, the relationship between amino acid tracers uptake and molecular parameters in the context of the recent WHO classification is still unclear. This evidence concerns the gene SLC7A5 and brain neoplasm.