Moreover, previous data suggested [18F] FET PET imaging may allow a non-invasive evaluation of IDH mutation status in gliomas [7,8], even if IDH mutated and 1p/19q co-deleted oligodendrogliomas cannot be differentiated from glioblastomas and astrocytomas by [18F] FET PET [7]. Here, IDH2 is linked to central nervous system cancer.