MGMT and neoplasm: Our results and the findings of the studies of Lopci et al. [6] and Ribom et al. [12] with [11C]MET PET highlight an overall lack of correlation between the degree of amino acid tracers uptake and the methylation status of MGMT promoter: in comparison with the previous reports mentioned above, we used a three-dimensional VOI for the assessment of semiquantitative PET parameters to evaluate better a possible heterogeneity of amino acid metabolism in the tumor.