Suppression of oncogene HMGA2 [18], inhibition of stemness phenotype [19,20], reduction of phosphorylation of carcinogenic signaling as AKT [21], influence in immunomodulation [22], suppression of proliferation [23,24] and control of invasion/migration [25,26] are among the different mechanisms by which let-7 can modulate tumor prognosis. The gene discussed is HMGA2; the disease is neoplasm.