For example, Cao et al. recently found that murine C2C12 myoblasts cultured in BMP-9 conditioned medium (collected 48 h after infection of HCT116 cells by Ad-BMP9) had less Bglap transcripts (Osteocalcin) in the presence of the Notch pathway inhibitors (Ad-dominant negative Notch1 and DAPT, γ-secretase inhibitor), as compared to BMP-9 alone [317]. Here, GDF2 is linked to infection.