Moreover, a single-nucleotide polymorphism (SNP) in exon 9 of the gene encoding FGFR4 results in the substitution of glycine for arginine at codon 388 (388 Gly/Arg) in the transmembrane domain and is associated with poor outcome in high-grade soft tissue sarcoma, lung, and breast cancers [26,27,28]. Here, FGFR4 is linked to breast cancer.