Effects of raloxifene were studied in the Mouse Motor Neuron-Like Hybrid Cell Line (NSC-34) model of amyotrophic lateral sclerosis (ALS) that stably expresses the 25-kDa C-terminal fragment of transactive response DNA binding protein 43 kDa (TDP-43) (i.e., TDP-25 cells). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.