DHCR24 and early-onset autosomal dominant Alzheimer disease: For example, the mechanisms were studied whereby desmosterol [3-β-hydroxysterol delta-24-reductase (DHCR24)], also named SELective Alzheimer’s Disease INdicator-1 (seladin-1), may be involved in the potential role of SERMs in their effects in Alzheimer’s disease [103].