Similar involvement of LOX in tumour dissemination was reported for undifferentiated pleomorphic sarcoma (UPS), where HIF1 alpha promoted the expression of PLOD2, and PLOD2 inhibition led to a decrease in collagen deposition, organisation and maturation, and a decrease in lung metastases [107]. The gene discussed is PLOD2; the disease is undifferentiated pleomorphic sarcoma.