The overexpression of these miRNAs was shown to promote the suppression of pituitary tumor cell proliferation, migration, and invasion, respectively, as well as inhibiting the expression of proteins involved in EMT (i.e., Twist, vimentin, and N-cadherin), in a mechanism sex determining region Y-box protein 5 (Sox5)-mediated, revealing these miRNAs as potential selective therapeutic targets for invasive pituitary tumor. Here, SOX5 is linked to pituitary tumor.