NES and pancreatic neoplasm: Xu et al. [81] investigated whether exosome miRNAs isolated from conditioned medium of human pancreas tumor cell lines (PANC-1, MIA-PaCa-2, BxPC-3), the human pancreas nestin expressing cell line (hTERT-HPNE) as representative of healthy pancreas, and from plasma samples of 15 patients with primary pancreas tumors and 15 HC, could be associated with localized pancreatic cancer.