PRL and gonorrhea: Among the total of these 850 target genes, authors selected the 10 genes with the highest degree of connectivity with the three upregulated and three downregulated differentially expressed miRNAs, and found that the majority of these 10 genes were potentially regulated by miR-489 and miR-520b, suggesting these two miRNAs as potential markers for the diagnosis and treatment of aggressive PRL-PAs.