Pharmacological inhibition of Bcl-xL causes thrombocytopenia in mice and humans, first demonstrated with drugs such as navitoclax (ABT-263) and ABT 737 [19,20,25]; however, in addition to Bcl-xL, they also inhibited prosurvival Bcl-2 and Bcl-w. The gene discussed is BCL2L1; the disease is Thrombocytopenia.