Cytoscape network analysis (see the methods section) revealed that the proteins encoded by these 198 genes formed a network that included the cell cycle and immune response regulators JUN (jun proto-oncogene), FOS (Finkel-Biskis-Jinkins osteosarcoma) and p53 (encoded by the gene TP53) as central nodes (Figure 3b). This evidence concerns the gene TP53 and osteosarcoma.