Moreover, exploration of significantly modulated pathways after the infection of Caco-2 cells by WT showed that, together with p53, NF-κB signaling was induced including the pathway genes TNFR, A20, caspase-8, p65(RelA)NF-κB, and CPB/p300, which modulate cell death and pro-inflammatory signaling (Figures S2 and S3). Here, CASP8 is linked to infection.