The six downregulated genes in microgravity, HLA-DPA1 (log2FC = −1.785, p-value = 0.002), HLA-DQA1 (log2FC = −1.65, p-value = 0.003), HLA-DPB1 (log2FC = −1.83, p-value = 0.0007), HLA-DMB (log2FC = −1.64, p-value = 0.002), CXCL12 (log2FC = −1.52, p-value = 0.001) and TNFSF13 (log2FC = −2.2, p-value = 0.001) (Figure 5C), were downregulated in READ and were enriched in “intestinal immune network for IgA production” pathway, which is well-known in colorectal cancer [53]. This evidence concerns the gene HLA-DPB1 and colorectal cancer.