CA9 and cancer: Overall, the methodology used to determine the inhibitory constants for the various compounds determined in the papers discussed above, and validated by independent technologies (see above), represent bona fide, accurate data, which in no way compromise the development of CA IX and CA XII-specific inhibitors for validation in preclinical cancer models and in clinical trials, based on the vast biological literature demonstrating CA IX/CA XII as promising cancer therapeutic targets in hypoxic solid tumors.