Strikingly, miR-22-3p expression was repeatedly reported to be downregulated in mouse and human HCC [14,15] and shown to target oncogenic factors such as histone deacetylase 4 (HDAC4), ezrin (EZR), and basigin (CD147) [14,15,16]. The gene discussed is HDAC4; the disease is hepatocellular carcinoma.