IFNG and non-small cell lung carcinoma: Gene expression signatures (IFN-γ signaling and activated T-cells associated with improved OS with second-line atezolizumab in advanced NSCLC [11], tumor-specific genotypes (such as genomic alterations in EGFR, ALK, KRAS, etc., and what is more, their interrelatedness with TMB) have been correlated to immunotherapy response.