Furthermore, the role of ROS generated by NADPH oxidase by specific inhibition of NADPH oxidase activity with the antioxidant apocynin was evaluated in a pilocarpine-induced Temporal Lobe Epilepsy (TLE) model, and a decreased ROS generation in the hippocampal regions of the brain was observed, indicating that NADPH oxidase dependent OS is involved in SE induced neurodegeneration and conclusively suggested that intensive research on NADPH oxidase inhibitors as well as their mechanism of actions might present a promising target for therapeutic interventions in TLE [31]. Here, FMO5 is linked to temporal lobe epilepsy.