We found significant decreases in the serum concentrations of adiponectin (p = 0.002) and increases in the leptin serum levels (p < 0.001) and the leptin–adiponectin ratios (p = 0.002) in patients with schizophrenia with MetS in comparison to patients without MetS (Table 2). The gene discussed is ADIPOQ; the disease is schizophrenia.