PDK4 and obesity due to melanocortin 4 receptor deficiency: To study the effect of the HFD-induced obesity in the GCs response, we assessed the dexamethasone-induced expression of FKBP51, PDK4, and KLF15 as readouts to evaluate GC response in the liver, skeletal muscle (gastrocnemius), and white adipose tissue (epididymal fat).