A few clinical phenotypes are associated with mutations in some of these proteases; interestingly, the majority of these have a neurological presentation (e.g., Gilles de la Tourette syndrome resulting from a defect in Mitochondrial inner membrane protease 2 [179], Parkinson’s Disease with Ser protease HTRA2 [180] and PARL (Presenilins-associated rhomboid like) [181]. The gene discussed is PARL; the disease is Tourette syndrome.