Neo-vascularization in GBM is mainly mediated by vascular endothelial growth factor (VEGF), basic fibroblast growth factors (bFGF), hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), matrix metallopeptidases (MMPs), and angiopoietins (Angs) (reviewed by [160]). The gene discussed is VEGFA; the disease is glioblastoma.