In a study of 108 GIST patients, the phosphorylation of p70S6K and 4E-BP1 was separately detected in KIT-mutated GISTs at 38%, in PDGFRA-mutated GISTs at 83%, and in wt GISTs at 74% [79]. This evidence concerns the gene EIF4EBP1 and gastrointestinal stromal tumor.