Tapia and colleagues investigated the activation of PI3K/AKT/mTOR signals in gastric cancer (GC), with the overexpression of most important target proteins of the pathway, such as PI3K, AKT, p-AKT, p-mTOR, p-4E-BP1, P70S6K1, p-P70S6K1, eIF-4E, and p-eIF-4E proteins in tumor tissue [120]. This evidence concerns the gene PIK3CA and gastric cancer.