The poor prognosis and early recurrence of OSCC is known to correlate with the simultaneous high levels of C-reactive protein (CRP), cancer-embryonic antigen (CEA) and squamous cell carcinoma antigen (SCCA), elevated white blood cell count, absolute neutrophil and platelet count, low expression of Caspase-3, high expression of p53 and bcl-2, and no reduction in Ki-67 expression in tumor tissue. This evidence concerns the gene MKI67 and neoplasm.