SH2D1A and juvenile idiopathic arthritis: Although no direct robust functional consequence has been described in literature, SH2D1A, which is a mediator in cytolytic pathways as key activator of T- and NK cell-cytotoxicity, showed differential gene expression associated with specific immunopathologies as is the case of systemic juvenile idiopathic arthritis, associated with the potential onset of macrophage activation syndrome [73].