Described by Alois Alzheimer in 1906 [4,5], AD is characterized by the presence of senile plaques (comprised of amyloid-β peptide (Aβ) [6,7,8]) and neurofibrillary tangles (NFTs) (formed by the aggregation of hyperphosphorylated tau [9,10,11]) in the brain, causing marked glial activation and loss of neurons and synapses [12]. Here, MAPT is linked to Alzheimer disease.