M2 differentiation is induced by CAF-secreted molecules such as Chitinase 3 Like 1 (Chi3L1), C-X-C motif chemokine 12 (CXCL12) and interleukin 6 (IL-6) in breast [16], prostate [21] and pancreatic cancers [22], respectively. This evidence concerns the gene IL6 and familial pancreatic carcinoma.