The exosomal tetraspanins CD9 and CD81, together with integrin αvβ3, were shown to be involved in the targeting and uptake of exosomes by dendritic cells, and a complex of tetraspanin-8 with integrin subunit CD49d (α4) determines the selective targeting and uptake of tumor-derived exosomes by endothelial cells [83]. The gene discussed is TSPAN8; the disease is neoplasm.