For example, in a very elegant study, Wu and collaborators showed that two hypoxia-induced miRNAs, miR-25 and miR-93, repressed cyclic GMP-AMP synthase (cGAS) expression during hypoxia, via targeting the epigenetic factor NCOA3 in breast cancer cells, which lead to hypoxic tumor cells to escape immunological responses induced by damage-associated molecular patterns [65]. The gene discussed is CGAS; the disease is breast cancer.