GJA1 and melanoma: Taking into consideration that Cx43 channels are permeable to miRNAs, that Cx43-GJs have been implicated in the transfer of miRNAs in other cellular and pathophysiological contexts [31], and the finding that Cx43-GJ inhibition impaired the levels of RNA molecules transferred from hypoxic melanoma to immune cells (Figure 2), we hypothesized that hypoxic melanoma cells may transfer HRMs to immune cells via Cx43-GJs.