For example, it has been observed that Cx43-GJICs increase tumor immunogenicity via STING-mediated production of type I interferon (IFN) by colorectal tumor associated-DCs that acquire cancer cell-generated cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) by Cx43-GJs [51]. Here, GJA1 is linked to colorectal neoplasm.