Alteration in circulating levels of chemokines like CXCL8 (IL-8), CCL2 (Monocyte Chemoattractant Protein-1 (MCP-1), CCL26 (Eosinophil Chemotactic Protein-3 (Eotaxin-3), CCL5 (Regulated on Activation of Normal T cell-expressed and secreted (RANTES) entities) CXCL10 (γ-Interferon-inducible Protein-10 (IP-10) or of chemokines receptors (e.g., fractalkine receptor-CX3CR1) are associated with subclinical or proclaimed cardiovascular pathology (e.g., MI, CAD, atherosclerosis) or with cardiovascular death [304,305,306]. The gene discussed is CCL5; the disease is atherosclerosis.