In particular, pro-inflammatory cytokines like interleukin-2 (IL-2), IL-6, soluble IL-6 receptor, tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) are increased while anti-inflammatory cytokines like IL-4 and IL-10 are decreased during depressive disorders [301]. This evidence concerns the gene TNF and depressive disorder.