CFTR and cystic fibrosis: According to research, a great proportion of CF patients fail to comply to the general, pancreatic enzyme replacement therapy (PERT), vitamin prescription and respiratory exercises due to lack of motivation, time and interest [2,3,4], whereas 11% of patients homozygous for the F508del-Cystic Fibrosis Transmembrane conductance Regulator (CFTR) mutation do not adhere to the Lumacaftor-ivacaftor medication prescription [5].