Since the PD-L1/CD274 expression of antigen-presenting cells might lead to an inhibition of antitumor responses following the presentation of tumor antigens to T cells, the aim of this study was to evaluate PD-L1/CD274 expression of blood monocytes and DC subpopulations in lung cancer patients undergoing PD1 inhibitor therapy with respect to their effect on therapy response and prognosis. Here, CD274 is linked to lung cancer.