NF1 and neurofibromatosis type 1: NF1 (OMIM#162200), also known as von Recklinghausen disease, is the most common among these disorders and shows a complete penetrance, high variable expressivity and an estimated incidence of 1 in 2500–3500 live births, independently from the ethnic group, race and sex [231,243,244,245,246,247,248].