TXNIP and cancer: Since VDUP1 is up-regulated by vitamin D, we may hypothesize that vitamin D may exert beneficial effects against NF1 tumours also by enhancing VDUP1 expression, opening the way to innovative therapeutic strategies in which vitamin D can be used in combination with other drugs, such as HDAC inhibitors, in order to increase VDUP1 expression, in turn promoting cell death of NF1 cancers.