CASP3 and cancer: We observed markedly increased expression of activated caspase-3 in the CTEN-knockdown cancer cell cultures compared to control siRNA-treated paired samples (median positive staining % nuclei per high power field: 5.19 (siCtrl, IQR 4.94–6.16) vs. 0.85 (siCTEN, IQR 8.46–10.14), p = 0.0027, respectively) with Western blot confirmation.