As well as exhibiting a relatively restricted pattern of expression in normal human tissues [19], CTEN appears to be the sole Tensin family member that mediates an oncogenic effect [20,21,22,23,24,25], with studies showing that it regulates integrin-mediated cell motility [22], is involved in a variety of signalling pathways [26,27] and also modulates Rho GTPase-activating proteins [28,29], suggesting that CTEN may broadly promote tumour cell invasion and metastasis [30]. Here, TNS4 is linked to neoplasm.