GATA2 and Decreased total monocyte count: In patients with MDS, a GATA2 deficiency should be suspected in case of suggestive clinical features, such as monocytopenia, NTM infections, recurrent HPV infections, and lymphedema; the report of the European Working Group of MDS in children and adolescent patients with a high-risk MDS (often presenting other cytogenetic abnormalities) should be considered for GATA2 deficiency [7].