AFP and neoplasm: In multivariable Cox regression analysis (Table 3), Framingham risk score (HR 1.53 (95% CI: 1.07–2.19); p = 0.019) was significantly associated with OS independently of tumor stage (BCLC B: HR: 1.04 (95% CI: 0.48–2.24), p = 0.928; BCLC C: HR: 1.21 (95% CI: 0.63–2.30), p = 0.568; BCLC D: HR: 2.34 (95% CI: 1.16–4.71), p = 0.018) and AFP levels (AFP > 400 IU/mL: HR: 2.04 (95% CI: 1.44–2.90); p < 0.001).