C-C Motif Chemokine Ligand 2 (CCL2, also known as monocyte chemotactic protein 1), was demonstrated to be involved in the progression of several cancers by activating PI3K/Akt, Rac GTPase and p42/44 MAPK signaling pathway [57,58] and by recruiting different subsets of myeloid cells [59,60]. This evidence concerns the gene AKT1 and cancer.