In fact, CXCR4, SPP1, ACKR3, CCL2, PTGS2, CD274 (PD-L1), CXCL11 were upregulated while CCL28, CCR1, CCR7 were down regulated in both comparisons (Figure 4D, blue boxes), suggesting this as a signature specific of the core region of the tumor. The gene discussed is SPP1; the disease is neoplasm.