In fact, in a glioma model, it has been shown that CCL20 [chemokine C-C motif ligand 20) is released by astrocytes in response to hypoxia and, by stimulating the CCR6-NF-κB signaling pathway, further enhances the HIF-1-mediated hypoxic response [78]. Here, NFKB1 is linked to central nervous system cancer.