CXCR4 and neoplasm: Interestingly, eleven of the ALA+/ALA− differentially expressed genes (ACKR3, CCL2, CXCL11, CXCL2, CXCL8, CXCR4, EGFR, IL1B, SPP1, TGFB1 and CCR1) were also upregulated in tumor patients, with respect to matched normal samples, and four others (CXCL1, CXCL5, CD274 and PTGS2) showed a similar, although not statistically significant, trend.