BRAF and colorectal carcinoma: Five CRC subtypes (from A to E) were identified according to proteomic data: (i) B and C subtypes included all CRCs characterized by hypermutation, MSI-H, POLE and BRAF mutations: B subtype was associated with the CIMP-H methylation subtype of the TCGA study, absence of TP53 mutations and chromosome 18 loss; C subtype was associated with a non-CIMP TCGA subtype.