Adenomas with CTNNB1 or BRAF mutations did not display mutations in other cancer-driver genes, whereas adenomas with APC mutations showed additional cancer-driver mutations (at the level of KRAS, NRAS, GNAS, AKT1, SOX9 and TP53 genes), whose number correlated with the degree of dysplasia and invasiveness [79]. This evidence concerns the gene TP53 and adenoma.