The WNT pathway resulted to be altered in 85% of MSS tumors and in 93% of MSI-H tumors: APC gene alterations were more frequent in MSS CRCs than in MSI-H CRCs (81% vs. 61%), while CTNNB1 and RNF43 gene alterations were less frequent in MSS CRCs than in MSI-H CRCs (6% vs. 25% and 4% vs. 53%, respectively) [24] (Figure 2). Here, RNF43 is linked to Marinesco-Sjogren syndrome.