Overall genomic alterations were similar in the majority of genes currently mutated, with some notable differences: in MSS CRC patients, TP53 and CTNNB1 alterations were more common in younger patients with CRC [19]; in the MSI-H cohort, most of genes displayed a similar frequency of alterations in the two age groups, but significant differences were observed at the level of APC and KRAS alterations more frequent among younger than older patients and BRAF alterations markedly more recurrent among older than younger CRC patients [19]. The gene discussed is TP53; the disease is colorectal carcinoma.