A study by Demidenko et al. has reported downregulation of eight (ABCA8, ABCB1, ABCC6, ABCC9, ABCC10, ABCD2, ABCG2, and ABCG4) and upregulation of two (ABCC4 and ABCG1) ABC transporters in prostate cancer compared to normal prostate tissue [93]. This evidence concerns the gene ABCB1 and Familial prostate cancer.